Matthew Tirrell is the dean of the Pritzker School of Molecular Engineering (PME) and the Robert A. Millikan Distinguished Service Professor at the University of Chicago. His personal research specializes in the manipulation and measurement of polymer surface properties. Dean Tirrell’s work has provided new insight into phenomena such as adhesion, friction, and biocompatibility, and contributed to the development of new materials based on self-assembly of synthetic and bio-inspired materials.
Before becoming dean of Pritzker Molecular Engineering in 2011, Tirrell served as the Arnold and Barbara Silverman Professor and chair of the Department of Bioengineering at the University of California, Berkeley, and as professor of materials science and engineering and chemical engineering and faculty scientist at Lawrence Berkeley National Laboratory. Prior to that, he was dean of engineering at the University of California, Santa Barbara for 10 years. Tirrell began his academic career at the University of Minnesota as an assistant professor in the Department of Chemical and Materials Engineering and later became head of the department. Tirrell also served as Deputy Laboratory Director for Science at Argonne National Laboratory, where he was responsible for integrating the laboratory’s research and development efforts and science and technology capabilities.
Tirrell received his BS in chemical engineering from Northwestern University and his PhD in polymer science and engineering from the University of Massachusetts. He has received many honors, including the Polymer Physics Prize of the American Physical Society and election to the National Academy of Sciences, National Academy of Engineering, and the American Academy of Arts and Sciences.
Matthew Tirrell is a pioneering researcher in the fields of biomolecular engineering and nanotechnology, specializing in the manipulation and measurement of the surface properties of polymers, materials that consist of long, flexible chain molecules. His work combines microscopic measurements of intermolecular forces with the creation of new structures. His work has provided new insight into polymer properties, especially surface phenomena, such as adhesion, friction, and biocompatibility, and new materials based on self-assembly of synthetic and bioinspired materials.
Host-microbiota interactions in the esophagus during homeostasis and allergic inflammation
M. Brusilovsky, R. Bao, M. Rochman, A.M. Kemter, C.R. Nagler, & M.E. Rothenberg. (2022) Gastroenterology 162(2): 521-534.e8.
Distinct molecular phenotypes involving several human diseases are induced by IFN-λ3 and IFN-λ4 in monocyte-derived macrophages
M. De, A. Bhushan, W.S. Grubbe, S. Roy, J.L. Mendoza, & S. Chinnaswamy. (2022) Genes Immun (in press).
VEGF-A, PDGF-BB and HB-EGF engineered for promiscuous super affinity to the extracellular matrix improve wound healing in a model of type 1 diabetes
M.J.V. White, P.S. Briquez, D.A.V. White, & J.A. Hubbell. (2021) NPJ Regen Med 6(1): 76.
Antigen multimers: Specific, sensitive, precise, and multifunctional high-avidity CAR-staining reagents
Y. Hu, G. Cao, X. Chen, X. Huang, N. Asby, N. Ankenbruck, A. Rahman, A. Thusu, Y. He, P.A. Riedell, M.R. Bishop, H. Schreiber, J.P. Kline, & J. Huang. (2021) Matter 4(12): 3917-3940.
A Multifunctional Neutralizing Antibody-Conjugated Nanoparticle Inhibits and Inactivates SARS-CoV-2
X. Cai, M. Chen, A. Prominski, Y. Lin, N. Ankenbruck, J. Rosenberg, M. Nguyen, J. Shi, A. Tomatsidou, G. Randall, D. Missiakas, J. Fung, E.B. Chang, P. Penaloza-MacMaster, B. Tian, & J. Huang. (2021) Adv Sci e2103240.
Generation of potent cellular and humoral immunity against SARS-CoV-2 antigens via conjugation to a polymeric glyco-adjuvant
L.T. Gray, M.M. Raczy, P.S. Briquez, T.M. Marchell, A.T. Alpar, R.P. Wallace, L.R. Volpatti, M.S. Sasso, S. Cao, M. Nguyen, A. Mansurov, E. Budina, E.A. Watkins, A. Solanki, N. Mitrousis, J.W. Reda, S.S. Yu, A.C. Tremain, R. Wang, V. Nicolaescu, K. Furlong, S. Dvorkin, B. Manicassamy, G. Randall, D.S. Wilson, M. Kwissa, M.A. Swartz, & J.A. Hubbell. (2021) Biomaterials 278: 121159.
High-throughput RNA sequencing of paraformaldehyde-fixed single cells
H.V. Phan, M. van Gent, N. Drayman, A. Basu, M.U. Gack, & S. Tay. (2021) Nat Comm 12(1): 5636.
Lymph Node-Targeted Synthetically Glycosylated Antigen Leads to Antigen-Specific Immunological Tolerance
C.D. Maulloo, S. Cao, E.A. Watkins, M.M. Raczy, A.S. Solanki, M. Nguyen, J.W. Reda, H.N. Shim, D.S. Wilson, M.A. Swartz, & J.A. Hubbell. (2021) Front Immunol 12: 714842.
Exosomes: Small vesicles with big roles in cancer, vaccine development, and therapeutics
A. Thakur, D.C. Parra, P. Motallebnejad, M. Brocchi, & H.J. Chen. (2021) Bioact Mater 10: 281-294.
Improving the Adjuvanticity of Small Molecule Immune Potentiators Using Covalently Linked NF-κB Modulators
F.W. Kimani, S. Manna, B. Moser, J. Shen, N. Nihesh, & A.P. Esser-Kahn. (2021) ACS Med Chem Lett 12(9): 1441-1448.